How to Use ZymCTRL Online

How to Use ZymCTRL Online

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The design of custom-tailored proteins has the potential to provide novel and groundbreaking solutions in many fields, including molecular medicine or environmental sciences. Among protein classes, enzymes are particularly attractive because their complex active sites can accelerate chemical transformations by several orders of magnitude. Since enzymes are biodegradable nanoscopic materials, they hold an unmatched promise as sustainable, large-scale industrial catalysts. Motivated by the enormous success of language models in designing novel yet nature-like proteins, we hypothesised that an enzyme-specific language model could provide new opportunities to design purpose-built artificial enzymes. Here, we describe ZymCTRL, a conditional language model trained on the BRENDA database of enzymes, which generates enzymes of a specific enzymatic class upon a user prompt. ZymCTRLgenerates artificial enzymes distant from natural ones while their intended functionality matches predictions from orthogonal methods. We release the model to the community.

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About Tamarind Bio

Provides a no-code, web-based platform and API that gives life scientists and researchers access to powerful AI and computational tools. Their services are designed to simplify complex bioinformatics tasks, particularly in structural biology, protein design, and drug discovery.

Tamarind Bio's Mission

Arm scientists with the tools to invent the future of biology and enable creative discovery.