Use Boltz Mol-1 Online
Commercially Available Boltz Mol-1 No-Code Web Server
AI-Powered Small Molecule Hit Discovery at Unprecedented Scale
Discover starting points for challenging biological targets in weeks, not months. BoltzMol-1 flips the economics of conventional high-throughput screening (HTS) by combining prospective affinity prediction with ultra-large chemical spaces—delivering validated hits on 6 out of 10 hard targets.
What is BoltzMol-1?
BoltzMol-1 is the premier hit discovery pipeline optimized for prospective small molecule design. Traditional high-throughput screening requires testing tens of thousands to millions of physical compounds, a resource-heavy process that often yields hit rates below 0.5% while tying up months of laboratory time.
Built upon the proven affinity prediction frameworks of Boltz-2, BoltzMol-1 transforms early-stage drug discovery. It operates across two flexible screening modes to rapidly deliver genuine starting points for medicinal chemistry campaigns:
In-Stock Catalog Ranking: Rapidly analyze and rank what is already buyable from in-stock chemical catalogs for quick laboratory turnarounds.
Ultra-Large Generative Screening: Dynamically generate and search an unprecedented, make-on-demand space comprising more than 74 billion compounds.
Built-In Developability: To ensure your compounds have favorable drug-like properties from day one, you can steer generation toward your program's specific property requirements. Every run automatically filters designs using our integrated absorption, distribution, metabolism, and excretion (ADME) models—guaranteeing good solubility and permeability at no extra compute cost.
Real-World Performance & Economics
BoltzMol-1 shifts discovery from speculative scaling to targeted, cost-effective accuracy. Below is how the pipeline performs in practice compared to conventional HTS methods.
Metric / Scenario | In-Stock Library Screen (Budget Tool Discovery) | Ultra-Large Generative Screen (Target Validation) | Traditional HTS Campaigns |
Chemical Search Space | In-stock buyable catalogs | 74+ Billion compounds (sampled down to 20k–100k) | Millions of physical library compounds |
Compute Cost | ~$5,000 | <$2,500 | N/A (High physical asset cost) |
Synthesis/Purchase Cost | ~$30 per compound tested | ~$300 per compound synthesized | Massive upfront infrastructure & reagent costs |
Timeline to Early Read | 2 to 3 weeks | 8 to 10 weeks | Many months |
Proven Experimental Success in the Lab
BoltzMol-1 does not just work in silico—it delivers validated biological results. Across testing on ten distinct targets, the majority of which were entirely dissimilar from the model's training data, BoltzMol-1 delivered validated hits on 6/10 targets while only requiring the synthesis and testing of 28 to 51 compounds per target.
These micromolar actives represent genuine, high-confidence starting points against notoriously difficult targets:
ROR1 (Pseudokinase): Confirmed binders across three orthogonal biophysical assays.
GPCRs (MRGPRX2 & GLP-2R): Found functionally active compounds in cell-based and biochemical assays.
PknB (TB Kinase): Successfully identified active hits in biochemical profiles.
LC3B & GABARAP (Autophagy Proteins): Validated functional activity in wet-lab environments.
STAT6: Actively investigating further signal generation from the commercial library.
What is Tamarind Bio?
Tamarind Bio is a pioneering, no-code bioinformatics platform built to democratize access to powerful computational tools for life scientists and researchers. Recognizing that cutting-edge machine learning models are often difficult to deploy, Tamarind Bio provides an intuitive, web-based environment that completely abstracts away the complexities of high-performance computing, software dependencies, and command-line interfaces.
The platform is designed to provide easy access to biologists, chemists, and other researchers who want to run experimental models with their data without needing a background in programming or cloud infrastructure. By handling the technical heavy lifting, Tamarind Bio empowers researchers to concentrate on their scientific questions, maximize their budgets, and accelerate the overall pace of therapeutic discovery. Data security remains a top priority, ensuring your proprietary target sequences and chemical structures are fully protected.
How to Run BoltzMol-1 on Tamarind Bio
Leveraging the power of BoltzMol-1 through Tamarind Bio's web interface requires a streamlined, code-free workflow:
Access the Platform: Log in to your account on the official tamarind.bio website.
Select BoltzMol-1: Navigate to the available computational biology tools and choose the BoltzMol-1 hit discovery pipeline.
Input Target Parameters: Provide your target protein parameters or sequence data. Define your screening strategy by choosing between ranking an in-stock buyable library or generating a library from the 74+ billion make-on-demand space.
Steer Property & ADME Constraints: Set the specific property boundaries required for your drug discovery program. Enable automatic screening parameters to filter designs through the built-in ADME models for solubility and permeability.
Launch & Prioritize Candidates: Initiate the run. The platform scales computational resources to deliver high-confidence affinity predictions within weeks. Use the interface to select the top-ranked candidates to send directly to the lab for synthesis and biophysical validation.